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Abstract: Molecularly imprinted polymers have been recognised as stable and easy-to-handle substitutes for antibodies and receptors in affinity-type separations, such as liquid chromatography. However, since the polymers have been obtained as blocks in most cases, several tedious and time-consuming procedures, such as grinding, sieving, sizing and column packing are required to use the polymers as chromatographic stationary phases. This presentation describes an in-situ approach to prepare molecularly imprinted polymer rods for immediate use as chromatographic separation media. The polymer preparation was carried out inside liquid chromatography columns in the presence of a template molecules to obtain rod-type imprinted polymers. The resultant polymer rods have been used for chiral or selective separation of drugs. This new approach for preparation can be expected to make molecular imprinting an easier and more versatile technique for preparing 'tailor-made" affinity media for liquid chromatography