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Reference type: Journal
Authors: Rao RN, Maurya PK, Kuntamukkala R, Vitthal WD, Talluri MVNK
Article Title: Molecularly imprinted polymer for selective extraction of 3-methylflavone-8-carboxylic acid from human urine followed by its determination using zwitterionic hydrophilic interaction liquid chromatography.
Publication date: 2011
Journal: Journal of Separation Science
Volume: 34
Issue: (22)
Page numbers: 3265-3271.
DOI: 10.1002/jssc.201100560

Abstract: A novel water-compatible molecularly imprinted SPE combined with zwitterionic hydrophilic interaction liquid chromatography method for selective extraction and determination of 3-methylflavone-8-carboxylic acid (MFA), the main active metabolite of flavoxate in human urine, was developed and validated. The effects of progenic solvents, pH, cross linker and amount of monomer were studied to optimize the efficiency and selectivity. The molecularly imprinted polymer showed good specific adsorption capacity with an optimum of 200 μmol/g at pH 7.5 and selective extraction of MFA from human urine. The recovery of MFA from human urine was >98%. The lower limit of quantification was 1.20 μg/mL. The proposed method overcomes the matrix effects of endogenous substances generally encountered during direct analysis of urine sample
Template and target information: 3-methylflavone-8-carboxylic acid, MFA
Author keywords: 3-Methylflavone-8-carboxylic acid, human urine, molecularly imprinted polymer, SPE, Zwitterionic hydrophilic interaction liquid chromatography


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