MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Balamurugan K, Gokulakrishnan K, Prakasam T
Article Title: Preparation and evaluation of molecularly imprinted polymer liquid chromatography column for the separation of Cathine enantiomers.
Publication date: 2012
Journal: Saudi Pharmaceutical Journal
Volume: 20
Issue: (1)
Page numbers: 53-61.
DOI: 10.1016/j.jsps.2011.06.004
Alternative URL: https://www.researchgate.net/publication/255987588_Preparation_and_evaluation_of_molecularly_imprinted_polymer_liquid_chromatography_column_for_the_separation_of_Cathine_enantiomers

Abstract: In this study molecular imprinting technology was employed to prepare a specific affinity sorbent for the resolution of Cathine, a chiral drug product. The molecularly imprinted polymer (MIP) was prepared by non-covalent molecular imprinting with either (+) or (-)-Cathine (threo-2-amino-1-hydroxy-1-phenyl propane; norpseudoephedrine) as the template. Methacrylic acid and ethylene glycol di-methacrylate were copolymerized in the presence of the template molecule. The bulk polymerization was carried out in chloroform with 2,2'-azobisisobutyronitrile as the initiator, at 5 C and under UV radiation. The resulting MIP was ground into powders, which were slurry packed into analytical columns. After removal of template molecules, the MIP-packed columns were found to be effective for the resolution of ()-Cathine racemates. The separation factor for the enantiomers ranged between 1.5 and 2.4 when the column was packed with MIP prepared with (+)-Cathine as the template. A separation factor ranging from 1.6 to 2.9 could be achieved from the column packed with MIP, prepared with (-)-Cathine as the template. Although the separation factor was higher with that previously obtained from reversed-phase column chromatography following derivatization with a chiral agent, elution peaks were broader due to the heterogeneity of binding sites on MIP particles and the possible non-specific interaction
Template and target information: Cathine, threo-2-amino-1-hydroxy-1-phenyl propane, norpseudoephedrine
Author keywords: enantiomer separation, Cathine, Chiral drug product, Molecularly imprinted polymers, template

  mipdatabase.com logo imprinters do it in bulk shirt  Science Teacher peptide mug  Perpetual student shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner