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Abstract: A novel flow injection electrochemiluminescence method combined with molecularly imprinted solid-phase extraction was developed for the determination of L-phenylalanine, in which {Ru(bpy}₃²⁺ was used as the luminophor and indium tin oxide glass was modified as the working electrode. Molecularly imprinted polymers, synthesized by self-assembly with functional monomer and crossing linker, were used for the selective extraction of L-phenylalanine. In order to overcome the drawbacks of traditional electrochemiluminescence cells such as high IR drop, high over-potential and so on, a novel electrochemiluminescence cell was developed. The enhanced electrochemiluminescence intensity was linearly related with the concentration of L-phenylalanine in the range from 1.0 x 10-7 to 5.0 x 10-5 g/mL with a detection limit of 2.59 x 10-8 g/mL. The relative standard deviation for the determination of 1.0 x 10-6 g/mL L-phenylalanine was 1.2% (n = 11). The method showed higher sensitivity and good repeatability, and was successfully applied for the determination of L-phenylalanine in egg white, chicken and serum samples. A possible mechanism for the enhanced electrochemiluminescence response on indium tin oxide glass is proposed
Template and target information: L-phenylalanine
Author keywords: Electrochemiluminescence, flow injection, l-Phenylalanine, molecular imprinting, Solid-phase extraction