MIPdatabase
Authors: McNiven SJ, Cheong SH, Levi R, Yokobayashi Y, Nakagiri T, Yano K, Karube I
Publication date: 1998
Chapter title: Application of molecular imprinting to the recognition and detection of bioactive materials.
Chapter number: 6
Page numbers: 90-108.
DOI: 10.1021/bk-1998-0703.ch006
Book title: Molecular and Ionic Recognition with Imprinted Polymers
Editors: Bartsch RA, Maeda M
Publisher: The American Chemical Society
City: Washington DC
Series title: ACS Symposium Series
Volume number: 703
Abstract: Research in our laboratory has been focused on the development of molecularly imprinted polymers (MIPs) which exhibit selectivites for various biologically active molecules. In an effort to create steroid-selective sensors we have thoroughly investigated the effect of various polymerization conditions on the selectivity of MIPs for testosterone. Separation factors (a) ranging from 3 to 10 were observed for a suite of similar steroids. Furthermore, we report a novel post-polymerization technique by which the selectivity of this type of MIP may be further enhanced. Diastereoselective recognition of peptide derivatives has also been achieved using a novel polymerizable valine derivative as a functional monomer. We have also developed an FIA-based sensor for the antibiotic chloramphenicol which relies upon the displacement of a chloramphenicol-dye conjugate from an MIP by the drug. The sensor is effective over a wide range of concentrations encompassing the therapeutic dosage
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