MIPdatabase
Authors: Gong GL, Jia L, Li H
Publication date: 2012
Article title: Synthesis and Characterization of Epothilone B Molecular Imprinted Polymers.
Page numbers: 37-41
DOI: 10.4028/www.scientific.net/KEM.501.37 Alternative URL: http://www.scientific.net/KEM.501.37
Proceedings title: Key Engineering Materials
Editors: Zhang C
Publisher: Trans Tech Publications
City: Switzerland
Volume number: 501
Conference information: Progress in Polymer Processing
Abstract: Molecular imprinted polymers (MIPs) for antitumor drug Epothilone B have been synthesized with bulk polumerization in order to specifically extract this agent in the present study. MIP was prepared by thermal polymerisation using Epothilone B as template, methacrylic acid as functional monomer, ethylene glycol dimethacrylate (EGDMA) as cross-linking agent. The best synthesis progenic solvent was ultimately determined when the bonding property of the polymer was studied. The selectivity of imprinted polymer on Epothilone B was also studied. The equilibrium binding experiments showed that the binding site of MIPs was heterogeneous with one binding site. Equilibrium dissociation constant was 3.37 mg/ml, the maximum apparent adsorption was 335 mg/g.
Template and target information: Epothilone B
Author keywords: Epothilone B, Molecular imprinting polymers (MIPs), molecularly imprinted
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