MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Hugon-Chapuis F, Pichon V
Article Title: Molecularly imprinted polymers for selective extraction of analytes from biological samples (Polymères à empreintes moléculaires pour l'extraction sélective de composés de milieux biologiques).
Publication date: 2007
Journal: Annales de Toxicologie Analytique
Volume: 19
Issue: (3)
Page numbers: 239-251.
DOI: 10.1051/ata:2007028

Abstract: The analysis of interest compounds from biological samples requires a procedure of pretreatment in order to preconcentrate the analytes and clean-up the matrix. Despite its attractive features, classical sorbents used in SPE retain analytes by non selective hydrophobic interactions that lead to a partial coextraction of interfering substances. So, sorbents displaying more selective interactions are powerful tools for the development of sensitive and more reliable methods. Immunoaffinity supports can be used to obtain a selective extraction. They are based on the immobilization of specificantibodies developed against the target analyte (Immunosorbent). Nevertheless, the cost and the time required to produce antibodies lead to the development of a new polymeric material: the Molecularly Imprinted Polymers (MIP). These supports possess molecular recognition sites designed for the analyte of interest. With performances similar to immunosorbents in terms of selectivity, MIPs present a better thermic and chemical stability and the cost of synthesis is also reduced. Like immunosorbents, their retention mechanism is based on molecular recognition. In most cases, the developed interactions during the extraction are non covalent like - hydrogen bondings, π-π or electrostatic interactions. The most common approach to the synthesis is the bulk polymerisation to obtain a monolithic polymer. MIPs for SPE can be conditioned in cartridges or directly integrated in the analytical system. Many applications have already highlighted the high potential of MIPs for the selective extraction of target compounds from biological samples.
Template and target information: Review - MIPs for SPE
Author keywords: Molecularly imprinted polymers, Solid-phase extraction, selectivity, biological samples


  SMI logo mug  Mug featuring the name Valerie spelled out in the single letter amino acid code  Lab Chick script shirt

Molecules Special Issue call      Appeal for information






Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:
US listings   UK listings

Searching for Molecular Imprinting books on Amazon.com:
Molecular Imprinting
Imprinted Polymers
Polymer Chemistry
Organic Chemistry
Biosensors

Find what you need at Amazon.com

Lab supplies from Amazon