MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Shi YF, Lv HL, Lu XF, Huang YX, Zhang Y, Xue W
Article Title: Uniform molecularly imprinted poly(methacrylic acid) nanospheres prepared by precipitation polymerization: the control of particle features suitable for sustained release of gatifloxacin.
Publication date: 2012
Journal: Journal of Materials Chemistry
Volume: 22
Issue: (9)
Page numbers: 3889-3898.
DOI: 10.1039/C2JM15680F

Abstract: Herein we have combined the molecular imprinting technique and thermally-initiated precipitation polymerization to develop novel molecularly imprinted poly(methacrylic acid) nanospheres (PMAA MIPNs) for sustained release of gatifloxacin (GFLX). In the process, ethylene glycol dimethacrylate (EGDMA) and GFLX were used as the cross-linker and template, respectively. The effects of reaction medium and concentration of the monomers such as MAA, EGDMA and GFLX were systematically investigated. Uniform nanospheres with diameter equal to 136.0 8.1 nm and particle dispersion index (PDI) equal to 1.01 were obtained when the total monomer concentration was 1 vol%, the EGDMA content was 70 mol% and the GFLX/MAA ratio was 1 : 15 (mol/mol). The drug loading profiles and in vitro release studies indicated that PMAA MIPNs are better drug delivery vessels and have an improved release profile than non-imprinted ones, which was attributed to the reinforced interaction between GFLX and PMMA side groups due to the specific GFLX molecular arrangement in the PMAA polymeric matrix. Based on these results, these novel PMAA MIPNs are a promising candidate for sustained release of GFLX
Template and target information: gatifloxacin, GFLX


  Double Bonds spoof movie poster mug  Chemistry peptide mug  Chemists are fun customisable shirt

Molecules Special Issue call      Appeal for information






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner