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Abstract: A sensitive and selective imprinted electrochemical sensor for the determination of oxacillin was developed based on indium tin oxide electrode. The proposed sensor was decorated with imprinted sol-gel film and cobalt nanoparticles-chitosan/β-cyclodextrin-multiwalled carbon nanotubes nanocomposites. The surface morphologies of the modified electrodes were characterized by scanning electron microscopy and transmission electron microscope. The stepwise assembly process and electrochemical behavior of the novel sensor were characterized by differential pulse voltammetry, cyclic voltammetry and Amperometric i-t response. The imprinted sensor displayed excellent selectivity toward oxacillin. Meanwhile, the introduced cobalt nanoparticles-chitosan and β-cyclodextrin-multi-walled carbon nanotubes exhibited noticeable amplified electrochemical response signal. The differential voltammetric anodic peak current was linear to oxacillin concentration in the range from 2.0 x 10-7 to 1.0 x 10-4 mol l-1, and the detection limit was 6.9 x 10-9 mol l-1. The proposed imprinted sensor was applied to the determination of oxacillin in human blood serum samples successfully. Copyright © 2011 John Wiley & Sons, Ltd
Template and target information: oxacillin
Author keywords: molecularly imprinted, Electrochemical sensor, oxacillin, β-cyclodextrin, Multi-walled carbon nanotubes, cobalt nanoparticles