Authors: Roy B
, Vo Duy S
, Puy JY
, Martin C
, Guitton J
, Dumontet C
, Périgaud C
, Lefebvre-Tournier I
Synthesis and Evaluation of a Molecularly Imprinted Polymer for Selective Solid-Phase Extraction of Irinotecan from Human Serum Samples.
Publication date: 2012
Journal: Journal of Functional Biomaterials
Alternative URL: http://www.mdpi.com/2079-4983/3/1/131/
Abstract: A molecularly imprinted polymer (MIP) was synthesized by non-covalent imprinting polymerization using irinotecan as template. Methacrylic acid and 4-vinylpyridine was selected as functional monomers. An optimized procedure coupled to LC-PDA analysis was developed for the selective solid-phase extraction of irinotecan from various organic media. A specific capacity of 0.65 μmol g-1 for the MIP was determined. The high specificity of this MIP was demonstrated by studying the retention behaviour of two related compounds, camptothecin and SN-38. This support was applied for the extraction of irinotecan from human serum samples
Template and target information: irinotecan
Author keywords: molecularly imprinted polymer, irinotecan, human serum, LC-PDA
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