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Reference type: Journal
Authors: Petrikovics I, Yu JCC, Thompson DE, Jayanna P, Logue BA, Nasr J, Bhandari RK, Baskin SI, Rockwood G
Article Title: Plasma persistence of 2-aminothiazoline-4-carboxylic acid in rat system determined by liquid chromatography tandem mass spectrometry.
Publication date: 2012
Journal: Journal of Chromatography B
Volume: 891-892
Issue: (1)
Page numbers: 81-84.
DOI: 10.1016/j.jchromb.2012.01.024
Alternative URL: http://www.sciencedirect.com/science/article/pii/S1570023212000542

Abstract: 2-Aminothiazoline-4-carboxylic acid (ATCA) was intravenously injected to rats in order to investigate its plasma distribution. ATCA was extracted from plasma samples by solid phase extraction (SPE) and molecularly imprinted polymer stir bar sorption extraction (MIP-SBSE). Detection and quantification of ATCA were achieved by using liquid chromatography-tandem mass spectrometry (LC-MS/MS). It was found that the intravenously injected ATCA concentration quickly decreased to half within 2.5 h in the rat system. However, after 2.5 h, the concentration of ATCA in plasma stayed constant at least 5 folds above the endogenous ATCA level for more then 48 h. This finding can be used for evaluating ATCA's diagnostic and forensic value as a biomarker for cyanide exposure
Template and target information: 2-aminothiazoline-4-carboxylic acid, ATCA
Author keywords: Diagnostic biomarker, Forensic biomarker, Cyanide exposure, 2-Aminothiazoline-4-carboxylic acid (ATCA), LC-MS, MS


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