Abstract: The molecularly imprinted polymeric microspheres(MIPMs) were prepared successfully via a single-step swelling in aqueous system,using polystyrene prepared by dispersion polymerization technique as seeds,vanillin as template molecule,methacrylic acid as a functional monomer,and ethyleneglycol dimethacrylate as a cross-linking agent.The polymeric microspheres were characterized by SEM,static adsorption and HPLC.The results showed that the as-prepared MIPMs exhibited high adsorption and good specific selectivity for vanillin.So while been used as stationary phase in liquid chromatogram,It could separate from ferulic acid analogues and complete baseline resolution realized.
Template and target information: vanillin
Author keywords: molecular imprinting technology, Seed swelling suspension polymerization, Vanillin, HPLC