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Book title: Selenoproteins and Mimics
Editors: Liu JQ, Luo GM, Mu Y
Publisher: Springer
City: Berlin Heidelberg
ISBN: 978-3-642-22236-8
Series title: Advanced Topics in Science and Technology in China

Abstract: Selenoenzyme, glutathione peroxidase (GPx), as one of the important antioxidants, plays an important biological role in human bodies and protects the biomembranes and other cellular components against oxidative damage. In consideration of its important biological roles and also for further exploration of the structural and functional importance of selenium in enzymes and for potential applications in the development of selenium related medicine, a lot of effort has been devoted to selenium-related biomimetic chemistry. Up to now, a great deal of GPx mimics have been reported. In this chapter, we will give a brief review, mainly of the nanoenzyme model constructed on the basis of nano-scale materials, bestowing small molecular micelle, polymeric micelle, surface imprinted nanoparticles, dendrimers and temperature-responsive microgels and so on. In combination with supramolecular strategy, nano-scale materials give us a wonderful platform to construct various enzyme mimics. These nanoenzyme models can act as useful tools for understanding the catalytic mechanism, and the relationship between the structure and functions
Template and target information: Review - selenoenzyme mimics