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Reference type: Journal
Authors: Croux D, Weustenraed A, Pobedinskas P, Horemans F, DiliŽn H, Haenen K, Cleij T, Wagner P, Thoelen R, De Ceuninck W
Article Title: Development of multichannel quartz crystal microbalances for MIP-based biosensing.
Publication date: 2012
Journal: physica status solidi (a)
Volume: 209
Issue: (5)
Page numbers: 892-899.
DOI: 10.1002/pssa.201100715

Abstract: Molecularly imprinted polymers (MIPs) offer a huge potential in the development of cheap small-scale disposable biomimetic sensors. They are suited for a wide variety of biological targets and are compatible with many different measurement techniques such as gravimetric sensing and impedance spectroscopy. One potential sensor platform for MIP-based biosensors is the quartz crystal microbalance (QCM). A 4-channel MIP/non-imprinted polymer (NIP) coated QCM biosensor array was developed on a single piece of quartz crystal. To study cross-channel frequency coupling of the resonance modes, a simulation of crystal designs using finite element analysis (FEA) modeling was created. Based on these simulations and using reactive ion etching (RIE) to create mesa-like structures on the crystal surface, crosstalk can be severely reduced. The improved functionality compared to the traditional QCMs was demonstrated by employing these mesa-type multichannel QCM (MQCM) crystals as an L-nicotine biosensor platform
Template and target information: l-nicotine
Author keywords: biosensor, finite element analysis, molecular imprinting, quartz crystal microbalance


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