MIPdatabase
Authors: Székely G, Fritz E, Bandarra J, Heggie W, Sellergren B
Article Title: Removal of potentially genotoxic acetamide and arylsulfonate impurities from crude drugs by molecular imprinting.
Publication date: 2012
Journal: Journal of Chromatography A
Volume: 1240
Issue: (1)
Page numbers: 52-58.
DOI: 10.1016/j.chroma.2012.03.092
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0021967312005377
Abstract: The present study describes the synthesis and preliminary testing of molecularly imprinted polymers (MIPs) as scavenger resins for removal of the genotoxic impurities (GTI) acetamide and arylsulfonates from active pharmaceutical ingredients (API). The MIPs were synthesized as monoliths using acetamide or methyl tosylate respectively as templates. The polymers were crushed and subsequently tested in the batch and chromatographic mode for template recognition and potential removal efficiency. Both the acetamide and the tosylate MIPs exhibited a strong memory effect for their templates and selectivity with respect to model APIs. For instance the MIP for acetamide preferentially retained acetamide over other amides, such as formamide, acrylamide, methacrylamide, benzamide and N-tert-butylacrylamide. Moreover, passing model API crude contaminated with the acetamide through the MIPs led to the quantitative removal of acetamide.
Template and target information: genotoxic impurities, GTI, acetamide, arylsulfonates
Author keywords: molecular imprinting, Genotoxic impurities, API purification, Solid-phase extraction
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