MIPdatabase
Authors: Takano E, Tanaka F, Ooya T, Takeuchi T
Article Title: Molecularly Imprinted Microspheres for Bisphenol A Prepared Using a Microfluidic Device.
Publication date: 2012
Journal: Analytical Sciences
Volume: 28
Issue: (5)
Page numbers: 457-461.
DOI: 10.2116/analsci.28.457
Alternative URL: https://www.jstage.jst.go.jp/article/analsci/28/5/28_457/_article
Abstract: Spherical molecularly imprinted polymer particles for bisphenol A (BPA-MIP) were easily prepared by using a Y-junction microfluidic device. The sizes of the obtained BPA-MIP particles were found to be 86 μm with a narrow size distribution. The binding characteristics were investigated by drawing a binding isotherm to estimate the binding constant and by switching the polarity of solvents to examine the feasibility of use as a medium for affinity chromatography. When dichloromethane was used as a solvent, BPA was strongly bound to the spherical BPA-MIP particles based on hydrogen bond formation; after switching the solvent to methanol, BPA was eluted quantitatively due to the weakening of the hydrogen bonding, suggesting that the spherical BPA-MIP particles can be applied to affinity-type solid-phase extraction for BPA. As the present method can provide a diverse range of spherical MIPs without tedious procedures, MIP-based affinity media will be able to be more readily used as pretreatment and/or purification for various fields.
Template and target information: bisphenol A, BPA
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