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Abstract: A novel electrochemical sensor for the determination of theophylline based on ethylene glycol maleic rosinate acrylate as the cross linking agent and acrylic acid as functional monomer was fabricated by molecularly imprinted technology. A molecularly imprinted polymers (MIPs) membrane was synthesized on the surface of a glassy carbon electrode in vacuum drying oven by free radical polymerization method. The electrochemical behavior of the membrane was characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and chronoamperometry. Under optimum conditions, it was found that the response of peak currents was linear to the concentration of theophylline in range of 2.00 × 10-7 ~ 3.45 × 10-4 mol/L (linear regression coefficient = 0.9961) with the detection limit of 1.00 × 10-7 mol/L. The sensor not only has high selectivity, but also shows good stability and reproducibility. The sensor was applied to the determination of theophylline in theophylline sustained release tablets samples with recovery ranging from 95.6% to 103.8%.
Template and target information: theophylline
Author keywords: ethylene glycol maleic rosinate acrylate, theophylline, molecularly imprinted polymer, Electrochemical sensor