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Abstract: A new separation approach is demonstrated which combines electrochemical detection and molecular imprinting technique. The electrode was first partly covered with template molecules and next modified by silane coupling reagent, The template molecules were then extracted to form recognition cavities. Template of catechol and catecholamines can be prepared on a gold electrode by using 3- aminopropyltriethoxysilane as a insulation layer. The catechol- template electrode showed the usual diffusion-limited cyclic voltammogram of catechol and diminished response against all catecholamines. The selectivity between catechol and epinephrine was about 10. The epinephrine-template electrode exhibited the usual diffusion limit response against catechol and catecholamines. This means the selection took place mainly on the basis of the size of the template cavities. An electrode with a low template density showed a steady state dopamine response and the active density of template cavities was calculated as 3.26 fmol/cm(2) from the limiting current and that is 1/100 the density with an ideal situation