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Abstract: A series of Ephedrine-imprinted polymers were prepared with methacrylic acid (MAA) or 2-vinylpyridine (2-Vpy) as functional monomer and chloroform, acetonitrile or methanol as porogen. The equilibrium binding experiments results show that the imprinted polymer P1, prepared with MAA as the functional monomer, chloroform as the porogen, obviously exhibited a higher selectivity for Ephedrine. The specific binding capacity (Δ CP) and imprinting factor (IF) of P1 were 91.98 μmol/g and 4.42, respectively. The polymer prepared with methanol as the porogen showed the highest binding capacity for ephedrine. However, its higher binding capacity mainly originated from the unspecific binding. The recognition ability of the molecularly imprinted polymer was effectively influenced by the molar ratio of the template to functional monomer. The results of UV and 1H NMR experiments suggest that a template-monomer complex was formed based on hydrogen bonding and ionic interactions in the pre-polymeric mixture, and the molar ratio of template to monomer in the complex was 1:2. The equilibrium constants of the reactions for producing the template-monomer complexes in chloroform, acetonitrile and methanol were calculated to be 48 450.8, 45 813.3 and 23 418.2 (mol/L)-2, respectively.
Template and target information: ephedrine
Author keywords: molecular imprinting, Ephedrine, binding capacity, UV, functional monomer