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Abstract: With enoxacin as template molecule, methacrylic acid and 4-rinylpyridine as functional monomers, a molecularly imprinted polymer was prepared via a molecular imprinting technique. The molecularly imprinted polymer was investigated in equilibrium binding experiment to evaluate its adsorption property and selective recognition. Scatchard analysis showed that two classes of binding sites were formed in the enoxacin imprinted polymer under the studied concentrations. The dissociation constant (Kd1) and the apparent maximum binding capacity (Qmax) were Kd1=0.22 mmol/L, Qmax1=52.2 μmol/g for high affinity binding sites and Kd2=1.23 mmol/L, Qmax2=150.5 μmol/g for low affinity binding sites, respectively. The experiments of binding different substrates indicated that the imprinted polymer possessed a high selectivity and a high recognition ability for enoxacin. When it was used as a solid phase extraction sorbent, the imprined polymer effectively completed the clean-up and enrichment of the sample in the analysis of enoxacin from human serum.
Template and target information: enoxacin
Author keywords: molecularly imprinted polymer, enoxacin, molecular recognition, solid phase extraction