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Book title: Molecularly Imprinted Sensors
Editors: Li SJ, Ge Y, Piletsky SA, Lunec J
Publisher: Elsevier
City: Amsterdam
ISBN: 978-0-444-56331-6

Abstract: The most common methods of chiral analysis are high-performance chromatographic and electromigration methods, which are based on application of appropriate chiral selectors, exhibiting some differences in interaction with optical isomers of particular target analytes. Besides numerous classes of macromolecular ligands and biomolecules, for this purpose synthetic molecularly imprinted polymers (MIPs) can also be employed. Similarly, MIPs exhibiting some enantioselective interactions can be employed as molecular recognition elements with different signal transducers, which may lead to design of chiral sensors. Numerous such devices were developed with electrochemical detections, including potentiometric, amperometric, and voltammetric, field-effect transistor, or capacitance. There are also examples of design of optical devices involving MIPs based on measurement of absorption of light, luminescence, reflectometric interference spectroscopy, or surface plasmon resonance spectroscopy. For this purpose, mass detection employing quartz crystal microbalance is also employed. The main challenge in the design of enantioselective MIP-based sensors is to get a comparable efficiency of separation in a single operation unit of detection in case of sensors with the efficiency of chiral separation obtained by multiple unit operations of separation between stationary and mobile phases that take place in chromatographic processes
Template and target information: Review - MIP-based chiral sensors