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Abstract: In this work, two kinds of potentiometric sensors, based on the nano-sized molecularly imprinted polymer (MIP), were introduced for high selective determination of promethazine. The MIP nanoparticles were prepared by using two different methods including microemulsion polymerization and suspension polymerization in silicon oil, regarded as nano-MIP(1) and nano-MIP(2), respectively. Scatchard plots and the results of the rebinding experiments indicated that the binding sites of the nano-MIP(2) had more affinity to target molecules, compared to those of the nano-MIP(1). The MIP nanoparticles were used in fabrication of the potentiometric membrane electrodes. The selectivity of the sensors was tested respect to some organic and inorganic species. The nano-MIP(2) based sensor, showed higher selectivity and sensitivity, compared to the nano-MIP(1) based electrode. The former sensor, exhibited a Nernstian response (31.25 ± 0.8 mVdecade-1) in a concentration range of 1.0 x 10-8 to 1.0 x 10-2 M with a lower detection limit of 7.0 x 10-9 M, whereas the later sensor showed a Nernstian response (31.97 ± 0.6 mVdecade-1) in a concentration range of 1.0 x 10-7 to 1.0 x 10-2 M with a lower detection limit of 8.0 x 10-8 M. Both electrodes demonstrated a response time of 5 s, a high performance and a satisfactory long-term stability. The electrodes were applied for PMZ determination in syrup and serum samples.
Template and target information: promethazine
Author keywords: Promethazine, Molecularly imprinted polymer nanoparticles, Membrane electrode, suspension polymerization, Microemulsion polymerization