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Reference type: Journal
Authors: Nicholls IA, Matsui J, Krook M, Mosbach K
Article Title: Some recent developments in the preparation of novel recognition systems: A recognition site for the selective catalysis of an aldol condensation using molecular imprinting and specific affinity motifs for a-chymotrypsin using a phage display peptide library.
Publication date: 1996
Journal: Journal of Molecular Recognition
Volume: 9
Issue: (5-6)
Page numbers: 652-657.
DOI: 10.1002/(SICI)1099-1352(199634/12)9:5/6<652::AID-JMR316>3.0.CO;2-6

Abstract: Molecular imprinting and phage display library technologies are rapidly being accepted as useful techniques for the generation of ligand-selective recognition motifs. The use of molecular imprinting to produce a novel type II aldolase mimic selective for the cobalt(LT)-mediated aldol condensation of benzophenone and acetaldehyde is reported here, Furthermore, peptide motifs have been identified which are acting as 'affinity ligands' selective for the recognition of the enzyme alpha-chymotrypsin using phage display techniques


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