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Book title: Designing Receptors for the Next Generation of Biosensors
Editors: Piletsky SA, Whitcombe MJ
Publisher: Springer
City: Berlin, Heidelberg
ISBN: 978-3-642-32329-4
Series title: Springer Series on Chemical Sensors and Biosensors
Volume number: 12

Abstract: In this study, a new method to imprint molecular recognition sites into Au nanoparticles (NPs) composites is described. The method includes the electropolymerization of thioaniline-functionalized Au NPs in the presence of imprint substrates that exhibit affinity interactions with the thioaniline-functionalized Au NPs or with a co-added ligand associated with the electropolymerizable NPs. Exclusion of the imprint substrate from the composite leads to the formation of selective imprinted sites in the Au NPs matrices. The imprinted matrices are implemented for the sensing of explosives, herbicides, saccharides, and ions. π-Donor-acceptor interactions, ionic interactions and H-bonds, or ligand-substrate interactions are used to generate the imprinted sites. The coupling between the localized plasmon of the NPs and the surface plasmon wave of the support is used to amplify the dielectric changes occurring in the NPs matrices upon the binding of the analytes to the imprinted sites, thus enabling the surface plasmon resonance (SPR) transduction of the sensing events. The imprinted Au NPs matrices demonstrate highly selective, stereoselective, and chiroselective sensing performance.
Template and target information: Review - Au nanoparticle-based MIP sensors
Author keywords: electropolymerization, molecular imprinting, nanoparticles, sensors, surface plasmon resonance