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Reference type: Journal
Authors: Jiang YF, Li JJ, Zhong YQ, Luo G, Ma XX, Yin XY
Article Title: Study on targeted separation of atractylenolide IQ from traditional Chinese herbs by molecularly imprinted solid phase extraction.
Publication date: 2012
Journal: Chinese Pharmaceutical Journal
Volume: 47
Issue: (13)
Page numbers: 1077-1080.
Alternative URL: http://en.cnki.com.cn/Journal_en/E-E079-ZGYX-2012-13.htm

Abstract: OBJECTIVE: To establish a novel and efficient method for enriching low content active components from traditional Chinese herbs. METHODS: The enrichment of atractylenolide III was taken as an example. First, molecular imprinting polymers (MIPs) of atractylenolide III were prepared by precipitation polymerization using 1-Vinylimidazole as functional monomer. Second, the atractylenolide III MIPs were packed into solid-phase column to separate atractylenolide III and its analogues from the exracts of Herba Atractylodes Macrocephaia and Codonopsis pilosula. Moreover, the adsorption performance of MIPs for the target components was also investigated. RESULTS: Enrichment factor (EF) of MIP-SPE and C 18-SPE column were 78.90 and 51.56 μg g-1 respectively, suggesting that MIPs had better adsorption property than C 18; the precision and accuracy of the developed method were satisfactory with recoveries of 102.2% and LOD of 0.36 μg mL-1. CONCLUSION These results demonstrate the feasibility of molecularly imprinted solid phase extraction for enriching low content active components in traditional Chinese herbs
Template and target information: atractylenolide III
Author keywords: 1-vinylimidazole, Atractylenolide III, Low-content active component, molecularly imprinted polymers (MIPs), Solid-Phase Extraction (SPE)

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