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Abstract: The molecular imprinted polymer (MIP) was synthesized by precipitation polymerization with caffeine as template,methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EDMA) as cross-linker. Compared with non-imprinted polymer (NIP) particles, the prepared MIP sorbent showed high adsorption capacity and selectivity for caffeine. The maximum static adsorption capacity of the MIP and NIP sorbent for caffeine was 28.1 mg/g and 16.5 mg/g, respectively. The relatively selective factor value was 1.25. Using the caffeine-imprinted polymer as a solid phase extraction(SPE) sorbent, a novel sample pretreatment technique that can be coupled to high performance liquid chromatography (HPLC) had been developed for the determination of caffeine in tea and human plasma after administration of tea. The effects of the type and amount of elution solvents on the recovery of caffeine were investigated. After optimization of SPE profile, the caffeine extraction recovery of 97.5% was obtained when the following procedure was applied to MIPs cartridge: conditioning with 2 mL water, loading with water, washing with 2 mL water, eluting with 6 mL methanol-acetic acid (9:1, V/V). The recovery of caffeine on NIPs cartridge was only 54.9%.
Template and target information: caffeine
Author keywords: caffeine, molecular imprinted polymer, Solid-phase extraction, tea, human plasma