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Reference type: Journal
Authors: Shah N, Ha JH, Ul-Islam M, Park JK
Article Title: Chiral separation of phenylalanine using D-phenylalanine imprinted membrane containing L-phenylalanine imprinted submicron/nanoscale beads.
Publication date: 2012
Journal: Journal of Pharmacy Research
Volume: 5
Issue: (8)
Page numbers: 4425-4433.
Alternative URL: http://jpronline.info/index.php/jpr/article/view/14809

Abstract: A novel composite membrane (CM) consisting of L-Phenylalanine (L-Phe) imprinted P(MMA-co-EGDMA) submicron/nanoscale beads (LIBs) and D-Phe imprinted P(AN-co-AA) membranes (DIMs) or CMLIBDIMs were prepared for the first time using phase inversion technique. The preparation of CMLIBDIMs involved uniform dispersion of LIBs into the D-Phe incorporated P(AN-co-AA) solution using a simple physico-mechanical process. The prepared CMLIBDIMs and DIMs were separately evaluated for chiral separation using ultrafiltration of a D,L-Phe racemic mixture. CMLIBDIM had higher permselectivity (2.99), percent swelling ratio (397.413%), and water holding capacity (0.174 g g-1) than DIMs. The adsorption selectivity (1.01), rejection selectivity (0.56), and percent rejection (2.8% and 5.1% for D- and L-Phe, respectively) were relatively lower than obtained with DIMs. The prepared Phe imprinted composite membrane exhibited excellent chiral separation of Phe racemate solution due to high adsorption capacity, selective permeation and selective rejection compared to control.
Template and target information: l-phenylalanine, l-Phe
Author keywords: molecularly imprinted composite membranes, D-Phe imprinted membrane, L-Phe imprinted submicron, nanoscale beads

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