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Reference type: Journal
Authors: Liu X, Wei ZH, Huang YP, Yang JR, Liu ZS
Article Title: Molecularly imprinted nanoparticles with nontailing peaks in capillary electrochromatography.
Publication date: 2012
Journal: Journal of Chromatography A
Volume: 1264
Page numbers: 137-142.
DOI: 10.1016/j.chroma.2012.09.055
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0021967312014677

Abstract: The combination of microparticles of molecularly imprinted polymers (MIPs) with partial filling capillary electrochromatography (CEC) has previously been demonstrated for the enantiomer separation. In this paper, precipitation polymerization was used to prepare d-zopiclone imprinted nanoparticles (50 - 80 nm) by a strategy of the dilution of pre-polymerization mixtures. The influence of some important parameters on the preparation of MIPs nanoparticles, including template to monomer ratio, type and amount of cross-linking monomer, and functional monomer composition ratio were investigated. In addition, the effect of separation condition, e.g., organic modifier content, pH value and salt concentration of buffer, on the electrochromatographic behavior of the MIP nanoparticles were studied. In spite of lower selectivity factor (1.11), high column performance (theoretical plates 41,400) of template was obtained and the resolution of enantiomers separation was 4.75 under the optimized conditions. Compared to the previously reported MIP microparticles, the MIP nanoparticles showed good peak symmetry and an ability of high speed separation (< 15 min) in CEC mode
Template and target information: d-zopiclone
Author keywords: molecularly imprinted polymer, Partial filling capillary electrochromatography, nanoparticles, Zopiclone, Enantiomers separation


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