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Abstract: Current ophthalmic drug delivery systems are insignificant as it gives low bioavailability and short time drug release, for example: eye drops, in which 95% of drug is lost due to absorption through the conjunctiva or through the tear drainage. Drug delivery through therapeutic contact lenses enhances the bioavailability of drug by controlled and extended release on the eye surface and enhances the residence time of drug in eye cavity. In this review focus has been made on developing drug eluting contact lens using two techniques like nanoparticle encapsulated therapeutic contact lens and molecularly imprinted therapeutic contact lens. Therapeutic contact lenses can prevent infections and unwanted reaction of eye tissues and can act as drug reservoir for treatment of several other ocular pathologies. The contact lenses prevent the drug from being lost to tear drainage by releasing the drug into tear layer on the contact lens, where it ultimately diffuses into the eye. Ex: hydro gel soft contact lens. Thus, this review will focus on potential of therapeutic lenses as effective dosage form for ophthalmic drug delivery system.
Template and target information: Review - drug delivery from conact lenses
Author keywords: Therapeutic contact lens, Ophthalmic drug delivery system, hydro gel soft contact lens