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Abstract: Properties of tailored imprinted sol-gels are extremely dependent on the synthesis conditions and on the nature of the reagents used due to the diversity of combinatory interactions among the sol-gel components and the large number of chemical requirements for the sol-gel process. In this paper, methyltrimethyl orthosilicate was used as precursor to create molecularly imprinted polymers against the β-lactamic antibiotic nafcillin under different experimental conditions. A 22 member-library of imprinted sol-gels against nafcillin, and the respective control materials, was produced. Screening of the library members was performed by room temperature phosphorescence (RTP) flow-injection analysis and by batch RTP re-binding assays. A 2^2 factorial experimental design was also performed in selected sub-libraries of imprinted sol-gels as a function of the template and the additive concentrations, both using acid and basic catalysis
Template and target information: nafcillin
Author keywords: Molecular imprinted sol-gel materials, Molecularly imprinted library, Factorial design, nafcillin