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Authors: Li Y, Wen TT, Xue C, Han Q, Wang Y, Hong JL, Zhou XM, Jiang HJ
Article Title: RGO LBL modified biomimetic electrochemical sensor for detection of Sildenafil in herbal sexual health products.
Publication date: 2013
Journal: Biosensors and Bioelectronics
Volume: 42
Page numbers: 287-292.
DOI: 10.1016/j.bios.2012.10.056
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0956566312007312
Abstract: In this work, a highly sensitive and selective biomimetic electrochemical sensor for Sildenafil in herbal sexual health products was prepared. Reduced graphene oxide (RGO), a novel highly conductive material was used to modify glassy carbon electrode (GCE) through layer-by-layer (LBL) self-assembly. The conductive molecularly imprinted films were constructed on the functional electrode surface using Sildenafil as template molecules, p-phenylenediamine (p-PD) as functional monomers. The obtained molecularly imprinted electrochemical sensor (MIES) was successfully used to detect Sildenafil in herbal sexual health products. The limit of detection (LOD) was 6.2 nmol L-1. The recoveries for the spiked Sildenafil contents were in the range of 92.34 - 97.71% with the RSD < 2.31%. The selective efficiencies for Sildenafil and other structurally related analogues only slightly varied from 0.93 to 1.09
Template and target information: Sildenafil
Author keywords: Sildenafil, Layer-by-layer, self-assembly, Biomimetic electrochemical sensors, molecular imprinting
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