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Abstract: A molecularly imprinted polymer for cefotaxime (CTX-MIP) was synthesized by the molecular imprinting technique using cefotaxime (CTX) as template molecule, α-methacrylic acid (MAA) as functional monomer, ethylene glycol dimethacrylate (EGDMA) as cross linking agent. By using the cefotaxime molecularly imprinted polymer as sorbent in solid-phase extraction column, a molecularly imprinted solid phase extraction-capillary electrophoresis (MISPE-HPCE) method was developed for the determination of cefotaxime residue in milk. The results showed that cefotaxime imprinted polymer exhibited a higher selectivity to cefotaxime compared with that of the non imprinted polymer. The linear range of cefotaxime was in the range of 0.5-100 mg/L, and the correlation coefficient was 0.9994. The recoveries at three spiked concentration levels of 10, 50, 100 mg/L were 78%, 84% and 86%, respectively, with RSDs of 3.5%-4.5%. The limit of detection (LOD, S/N=3) and the limit of quantitation (LOQ, S/N=10) were 98.52 μg/L and 329.0 μg/L, respectively. The method could meet the requirements for veterinary drug residue analysis.
Template and target information: cefotaxime, CTX
Author keywords: molecularly imprinted solid phase extraction, capillary electrophoresis, cefotaxime, milk