MIPs logo MIPdatabase      MIP2020 Conference logo Use this space
Custom Search
Reference type: Journal
Authors: Huynh TP, Pietrzyk-Le A, Bikram KC, Noworyta KR, Sobczak JW, Sharma PS, D'Souza F, Kutner W
Article Title: Electrochemically synthesized molecularly imprinted polymer of thiophene derivatives for flow-injection analysis determination of adenosine-5'-triphosphate (ATP).
Publication date: 2013
Journal: Biosensors and Bioelectronics
Volume: 41
Page numbers: 634-641.
DOI: 10.1016/j.bios.2012.09.038
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0956566312006446

Abstract: Two selective chemosensors for adenosine-5'-triphosphate (ATP) determination featuring molecularly imprinted polymer (MIP) film recognition units were fabricated. For imprinting, three different thiophene derivatives were used as functional monomers. That is, the uracil substituent of bis(2,2'-bithienyl)methane 2 complementarily H-bond paired the adenine moiety of ATP, the boronic acid substituent of thiophene 3 covalently bound vicinal diols of the ribofuranose moiety, and amide substituents of bis(2,2'-bithienyl)methanes 4 bound to the pyrophosphate moieties. Different binding motifs adopted for the ATP recognition and the structure of the supramolecular pre-polymerization complex were optimized with the DFT computing at the B3LYP/3-21G( ) level. MIP films were prepared by potentiodynamic electropolymerization of this complex with the imprinting factor of 9.47 0.2. An analytical signal was transduced with a 10-MHz resonator of EQCM and a Pt electrode for the piezoelectric microgravimetry (PM) and capacitive impedometry (CI) determination of ATP, respectively, under FIA conditions. Analytical properties of the MIP film were unraveled by spectroscopic ellipsometry, XPS, IRRAS, and DPV. The limit of detection was 0.1 and 0.2 μM for the PM and CI chemosensor, respectively, being an order of magnitude lower than the ATP concentration in biological systems. Moreover, cross-selectivity was demonstrated with the adenosine-5'-diphosphate (ADP) imprinting and ATP discrimination
Template and target information: adenosine-5'-triphosphate, ATP
Author keywords: Adenosine-5'-triphosphate ATP, molecularly imprinted polymer, Piezoelectric microgravimetry, Capacitive impedometry, flow-injection analysis

  Bag featuring the name Piyush spelled out in symbols of the chemical elements  Mug featuring the name Francis spelled out in the single letter amino acid code  Meerkat somebody mention coffee mug

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner