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Reference type: Journal
Authors: Panahi HA, Feizbakhsh A, Khaledi S, Moniri E
Article Title: Fabrication of new drug imprinting polymer beads for selective extraction of naproxen in human urine and pharmaceutical samples.
Publication date: 2013
Journal: International Journal of Pharmaceutics
Volume: 441
Issue: (1-2)
Page numbers: 776-780.
DOI: 10.1016/j.ijpharm.2012.10.004
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0378517312009441

Abstract: A drug imprinting polymer based on suspension polymerization was prepared with N,N-dimethylacrylamide and 1-(N,N-bis-carboxymethyl) amino-3-allylglycerol as functional monomers, N,N methylene diacrylamid as the cross-linker, naproxen as the template and 2,2'-azobis (2-methylbutyronitrile) as the initiator. The drug imprinted polymer was characterized by Fourier transform infrared spectroscopy, elemental analysis, thermogravimetric analysis and transmission electron microscopy. The imprinted polymer of agglomerated micro-particles with multi-pores was used for solid phase extraction. The drug imprinted polymer sorbent was selective for naproxen. The profile of the naproxen uptake by the sorbent reflects good accessibility of the active sites in the imprinted polymer sorbent. In addition, the equilibrium adsorption data of naproxen by imprinted polymer were analyzed by Langmuir isotherm models. The developed method was utilized for determination of naproxen in pharmaceutical and human urine samples by high performance liquid chromatography with satisfactory results
Template and target information: naproxen
Author keywords: naproxen, molecularly imprinted polymer, solid phase extraction, Pharmaceutical samples, human urine


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