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Reference type: Journal
Authors: Gholivand MB, Malekzadeh G, Torkashvand M
Article Title: Determination of lamotrigine by using molecularly imprinted polymer-carbon paste electrode.
Publication date: 2013
Journal: Journal of Electroanalytical Chemistry
Volume: 692
Page numbers: 9-16.
DOI: 10.1016/j.jelechem.2012.12.016

Abstract: By using a molecularly imprinted polymer (MIP) as a recognition element, construction of a high selective voltammetric sensor for lamotrigine (LTG) was performed. A LTG selective MIP and a non-imprinted polymer (NIP) were synthesized and then incorporated in the carbon paste (CP) electrodes. The sensor was applied for LTG determination using differential pulse voltammetric (DPV) method. The MIP-CP electrode showed very high recognition ability in comparison to NIP-CPE. Some parameters affecting the sensor response were optimized and then the calibration curve was plotted. Two dynamic linear ranges of 0.8 - 25 and 25 - 400 nM were obtained. The detection limit of the sensor was calculated as 0.21 nM. This sensor was used successfully for LTG determination in pharmaceutical preparations
Template and target information: lamotrigine
Author keywords: Lamotrigine, molecularly imprinted polymer, carbon paste electrode, DPV


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