Abstract: A fast and accurate method for detecting cephalosporin drugs residues in chicken muscles was established. 7-aminocephalosporanic acid molecular imprinted polymers (7-ACA MIP) was synthesized using 7-ACA as template molecules, 4-vinylpyridine as functional monomer and ethylene glycol dimethacrylate as cross-linking agent. Cephalosporin drugs (cefalexin, cefradine, cefoperazone and cefazdin) residues in chicken muscles was determined by molecular imprinted solid phase extraction-high performance capillary electrophoresis (MISPE-HPCE), using 7-ACA MIP as solid phase extraction materials. The recoveries of four drugs at different levels were in the range of 78.00% - 83.04%, and the relative standard deviations (RSD) were in the range of 2.18% - 3.79%. It indicated that MISPE-HPCE method may be suitable for analysis of cephalosporin drugs residues in chicken muscles
Template and target information: 7-aminocephalosporanic acid, 7-ACA, cephalosporin drugs, cefalexin, cefradine, cefoperazone, cefazdin
Author keywords: Molecular imprinted solid phase extraction, High performance capillary electrophoresis, 7-aminocephalosporanic acid, cephalosporin drug, Chicken muscle