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Reference type: Journal
Authors: Zhang J, Fu Q
Article Title: Preparation of ephedrine molecularly imprinted monolithic columns.
Publication date: 2006
Journal: Chinese Journal of Pharmaceutical Analysis
Volume: 26
Issue: (12)
Page numbers: 1760-1764.
Alternative URL: http://file.lw23.com/9/9f/9ff/9ff47500-5a3f-415b-8bdd-9a0bdb8ca652.pdf

Abstract: Objective: To prepare a monolithic molecularly imprinted polymer(mMIP) with specific recognition ability for the ephedrine molecule. Method: An ephedrine molecularly imprinted monolithic column was prepared by in situ polymerization using methacrylic acid (MAA) as a functional monomer, ethylene glycol dimethacrylate (EDMA) as a cross—linking agent, toluene and dodecanol as porogenic solvents, and 2,2'-azobisisobutyronitrile (AIBN) as an initiator. Results: The synthesis condition was optimized. The results showed the best ratio of template and functional monomer was 1:2 and the toluene content in porogen was 20—25%. Scanning electron microscopy and mercury intrusion porosimetry were used to identify the structural features of the mMIP. Results show the presence of three types of pore structure.The large through-pore structure allows mobile phase to flow through the column of mMIP at a low back pressure and the others may lead to the molecular recognition. Some chromatographic conditions such as the pH and the composition of the mobile phase were characterized. Conclusion: The ephedrine molecularly imprinted monolithic polymer has specific recognition ability for the ephedrine molecule. The ephedrine and pseudoephedrine were to be separated under optimized conditions.
Template and target information: ephedrine
Author keywords: molecularly imprinted polymer, Ephedrine, Pseudoephedrine, In situ technique

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