MIPdatabase
Authors: Prasad BB, Srivastava A, Tiwari MP
Article Title: Highly selective and sensitive analysis of dopamine by molecularly imprinted stir bar sorptive extraction technique coupled with complementary molecularly imprinted polymer sensor.
Publication date: 2013
Journal: Journal of Colloid and Interface Science
Volume: 396
Page numbers: 234-241.
DOI: 10.1016/j.jcis.2012.12.073
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0021979713000362
Abstract: This paper reports a combination of molecularly imprinted stir bar sorptive extraction and complementary molecularly imprinted polymer-sensor for the analysis of dopamine as a biomarker of several neurodegenerative diseases occurred at ultra trace level. This exploited iniferter initiated polymerization via ''surface grafting-from'' approach onto magnetic stir bar (for sorptive extraction) and multiwalled carbon nanotubes-ceramic electrode (for detection). Such hyphenation helped dual pre-concentration of dopamine in aqueous, biological and pharmaceutical samples. This enabled high sensitivity to achieve the stringent limit [limit of detection: 4.9 ng L-1, RSD = 2.4%, S/N = 3, cerebrospinal fluid] of clinical detection, without any problems of non-specific contributions and cross-reactivity
Template and target information: dopamine
Author keywords: Molecularly imprinted stir bar sorptive extraction, dopamine, ''Surface grafting-from'' approach, Differential pulse anodic stripping voltammetry, Real sample analysis
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