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Authors: Ogiso M, Aiba SI, Minoura N
Article Title: Preparation of molecularly imprinted polymer gel beads for adsorption of endotoxin.
Publication date: 2013
Journal: Kobunshi Ronbunshu
Volume: 70
Issue: (2)
Page numbers: 82-86.
DOI: 10.1295/koron.70.82
Alternative URL: https://www.jstage.jst.go.jp/article/koron/70/2/70_2012-0058/_article
Abstract: Endotoxins are a major component of the outer membrane of Gram-negative bacteria. Since they lead to multiple pathophysiological effects, efficient removal of endotoxins from biological and pharmaceutical products is essential. We successfully prepared polymer hydrogel beads with endotoxin adsorption sites by applying a molecular imprinting technique, using a triazine derivative as a functional monomer, that was polymerized in an inverse-phase suspension. The gel beads showed a high adsorption capacity for endotoxin, and exhibited a preferential binding for endotoxin rather than BSA. These results suggest that the gel beads can be employed for an endotoxin adsorbent. © 2013, The Society of Polymer Science, Japan
Template and target information: endotoxin
Author keywords: Endotoxin, Gel beads, molecularly imprinted polymer, suspension polymerization
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