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Abstract: Molecular imprinting is a process by which materials can be synthesized with highly specific binding sites for small molecules (Scheme 1). Scheme 1 Key: (a) Pre-polymerization complex formation between template (I) with functional monomers (M); (b) Co-polymerization with an excess of crosslinking monomer; (c) Extraction of template from imprinted binding site; (d) Rebinding of template molecule to imprinted binding sites. This report describes the imprinting of a dimer of 2'-deoxyadenosine using various polymer formulations. Rebinding studies with the dimer revealed a polymer formulation that showed evidence of selective uptake. This formulation is being used to develop an optimal molecularly imprinted polymer for oligonucleotides. Applications of these polymers are envisioned in sensor technology, separation media as well as chromatography