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Abstract: Novel molecular imprinted polymer (MIP) was synthesized by bulk polymerization,using olivetol as template molecule, methyl acrylic acid (MAA) as monomer, ethylene glycol dimethacrylate (EDMA) as crosslinker, toluene and dodecanol as solvent. MIP was characterized by the quilibrium binding experiments, scanning electron microscope (SEM) and fourier transform infrared spectrometer (FTIR). Then the polymer was applied to solid phase extraction (SPE) of olivetol from spiked wheat bran samples. From the quilibrium binding experiments, it showed that MIP had a better recognizability for the template molecule. Scatchard analysis showed MIP had specific absorption to olivetol with two classes of binding sites. The high and low binding sites dissociation constants were Kd1=0.021 μmol/mL, Kd2=1.002 μmol/mL, and the corresponding maximum binding capacity constants were Qmax1=18.74 μmol/g,Qmax2=135.9 μmol/g. Under the optimum conditions of solid phase extraction, the recoveries of olivetol on MIP cartridge were in the range of 97.8%–98.8%, and the relative standard deviations (RSDs) were 2. 8%–4.2 %, linearity range was between 0.1 and 100 μg/mL, the limit of detection (3S/N) was 0.062 mg/L. MIP cartridge had a stronger selectivity and a higher recovery, compared with NIP and commercial PLS cartridges.
Template and target information: olivetol
Author keywords: molecularly imprinted polymer, solid phase extraction, olivetol, Bulk polymerization