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Abstract: Corosolic acid, found in banaba leaves, is known to have an antidiabetic property. A promising technology for the isolation of corosolic acid is the use of molecularly imprinted polymers. Molecularly imprinted particles specific for the recognition of corosolic acid were prepared and optimized using the monomers methacrylic acid, 4-vinylpyridine and crosslinkers divinylbenzene (DVB), 2,2- bis-(hydroxymethyl)butanol trimethacrylate (TRIM), and ethylene glycol dimethacrylate (EDMA) in THF and MeOH in combination with various porogens, but only few yielded particle formation. The best polymeric particles specific for corosolic acid were obtained using 4-vinyl pyridine (4-VP) and divinylbenzene (DVB) at 25%-35% THF in acetonitrile at a higher crosslinking ratio. The best polymers were further evaluated by batch rebinding analysis. The binding characteristics and affinity distribution of corosolic acid on the imprinted particles was fitted to Freundlich Isotherm with a median binding affinity constant of 0.0457 mM-1 and heterogeneous binding affinity constant of (0.297), much lower than the heterogeneous binding affinity constant of controlled polymer (1.10).
Template and target information: corosolic acid, asiatic acid, dummy template
Author keywords: corosolic acid, asiatic acid, Molecularly imprinted polymers, banaba, tetrahydrofuran, precipitation polymerization