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Reference type: Book Chapter
Authors: Goldhaber-Pasillas GD, Choi YH, Verpoorte R
Publication date: 2013
Chapter title: New Methods of Analysis and Investigation of Terpenoid Indole Alkaloids.
Chapter number: 9
Page numbers: 233-272.
Alternative URL: http://www.sciencedirect.com/science/article/pii/B9780124080614000092

Book title: New Light on Alkaloid Biosynthesis and Future Prospects
Editors: Giglioli-Guivarc'h N
Publisher: Academic Press
ISBN: ISBN: 978-0-12-408061-4 ISSN: 0065-2296
Series title: Advances in Botanical Research
Volume number: 68

Abstract: Terpenoid indole alkaloids are biologically active compounds that have been used as pharmaceuticals among others as anticancer, antimalarial, antihypertensive and hypoglycemic agents for more than 40 years. Many efforts have been focused on their extraction, isolation, separation and structural elucidation by means of different approaches based on methodologies already established since the 1960s. New methodologies in extraction and sample preparation from different matrices include environmentally friendly techniques such as ionic liquids or supercritical fluid extraction as well as the synthesis of molecularly imprinted polymers. Chromatography combined with spectroscopy is still the preferred analytical tool for alkaloid analysis, but recent improvements in mass spectroscopy and nuclear magnetic resonance-based technologies have also been applied to areas of research such as toxicology, quality control, metabolic fingerprinting and metabolic profiling. This review is intended to provide a more general rather than an exhaustive overview on the new methods for terpenoid indole alkaloid analysis focusing on hyphenated high-performance liquid chromatography and mass spectrometry approaches. We will also discuss extraction methods and the strength and weaknesses of the different analytical tools for their application in targeted or non targeted approaches
Template and target information: Review - aanalysis of terpene indole alkaloids
Author keywords: Terpenoid indole alkaloids, high-performance liquid chromatography, mass spectrometry, High-speed counter-current chromatography, capillary electrophoresis, gas chromatography, Ionic Liquids, Quantitative nuclear magnetic resonance, Metabolic fingerprinting

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