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Reference type: Journal
Authors: Wang Y, Wu JH, Xue C, Wang RY, Wen TT, Hong JL, Hu Q, Li F, Zhou XM
Article Title: Dumbbell-shaped stir bar coated with dendrimer-based MIPs for selective extraction and analysis of vardenafil and its analogue sildenafil in health foods.
Publication date: 2013
Journal: Analytical Methods
Volume: 5
Issue: (17)
Page numbers: 4494-4500.
DOI: 10.1039/C3AY40211H

Abstract: A novel dendrimer-based molecularly imprinted polymers (MIPs) coated dumbbell-shaped stir bar (DSB) was developed to enrich and analyze two kinds of phosphodiesterase type 5 (PDE-5) inhibitors in health foods (Hfs). The MIPs, with vardenafil as the template molecule and methacrylic acid (MAA) as the functional monomer, were synthesized on the surface of the dendritic-grafting DSB which was filled with magnetic core as substrate. The MIPs-DSB possessed mechanical stability, high adsorption capacity and good selectivity for vardenafil and its analogue sildenafil. A method for the determination of vardenafil and sildenafil in Hfs was established by stir bar sorptive extraction (SBSE) coupled with HPLC-UV. The contents of vardenafil and sildenafil were found to be 3.65 and 2.66 μg g-1, respectively, and the average recoveries in spiked Hfs were 86.5-91.8% with a relative standard deviation (RSD) below 5%. All results revealed that the MIPs-DSB coupled with HPLC-UV could be applied to the highly selective extraction and sensitive determination of trace analytes in a complex matrix
Template and target information: vardenafil, phosphodiesterase type 5 (PDE-5) inhibitors, sildenafil, viagra, levitra


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