MIPs logo MIPdatabase      MIP2018 Conference website
Custom Search
Reference type: Journal
Authors: Zhang JK, Li M, Xu PD, Jiang SH, Liu YL, Chen Y, Liu LJ, Sha ZL
Article Title: Directly fast detection of digoxin in the serum sample by the synthetic receptor sensor.
Publication date: 2013
Journal: Materials Science and Engineering: B
Volume: 178
Issue: (18)
Page numbers: 1191-1194.
DOI: 10.1016/j.mseb.2013.07.007
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0921510713002547

Abstract: A novel biosensor (the synthetic receptor sensor) employing the molecular imprinted technology for the digoxin analysis is investigated. The molecularly imprinted polymer (MIP) modified electrode can specifically bind to the analyte in the sample without sample pretreatment. The digoxin analyzed by the MIP sensor was carried out in 1 mM K3Fe(CN)6 solution with the cyclic voltammetry. In the system, the K3Fe(CN)63-/Fe2(CN)64- redox couple was taking place. When the solution contains the digoxin, the MIP on the electrode will bind the digoxin. Further the redox system is interrupted and the peak current is decreased according to the digoxin concentration increasing. Digoxin is a glycosylated steroid-like drug. It is important for the heart disease treatment. However, since the digoxin toxic level is low, the drug remains in the blood sample must be monitored frequently. The device possesses many advantages, such as high specific recognition properties, good chemical and mechanical stability, simplicity and low cost of preparation, sensitive and label free determination. The reproducibility is good (CV < 5). The linear relationship between the digoxin concentration and the current is 1.28-128 nM, and a detection limit of 1.28 nM is achieved. The detection time is less than 5 min
Template and target information: digoxin
Author keywords: Digoxin, Molecularly imprinted polymers, Serum sample, Label free biosensor


  mipdatabase.com logo imprinters do it in bulk shirt  Science Teacher peptide mug  Perpetual student shirt

Molecules Special Issue call     Sensors Special Issue call






Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:
US listings   UK listings

Searching for Molecular Imprinting books on Amazon.com:
Molecular Imprinting
Imprinted Polymers
Polymer Chemistry
Organic Chemistry
Biosensors

Find what you need at Amazon.com

Lab supplies from Amazon