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Reference type: Journal
Authors: Ji SL, Zhang FF, Luo X, Yang BC, Jin GW, Yan JY, Liang XM
Article Title: Synthesis of molecularly imprinted polymer sorbents and application for the determination of aminoglycosides antibiotics in honey.
Publication date: 2013
Journal: Journal of Chromatography A
Volume: 1313
Page numbers: 113-118.
DOI: 10.1016/j.chroma.2013.08.072
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0021967313013411

Abstract: Aminoglycoside antibiotic (AA)-selective molecularly imprinted polymer (MIP) sorbent was synthesized by polymerization of methacrylic acid and ethylene glycol dimethacrylate in the presence of streptomycin as template molecule. The MIP sorbent was in detail characterized and its performance was evaluated by selecting four model AAs including streptomycin, gentamicin, spectinomycin and dihydrostreptomycin. Relative to non-imprinted polymer (NIP), the MIPs exhibited much higher recognizable capacity and specificity to the AAs and negligible adsorption for non-AAs as well. In combination of hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS), the MIP sorbent-based solid phase extraction (SPE) was able to effectively determine the residue of four model AAs in honey samples with recovery ranging from 90% to 110%. The limit of detection (and the limit of quantitation) of streptomycin, gentamicin, spectinomycin and dihydrostreptomycin was 4.5 (15.0), 2.4 (8.0), 6.0 (20.0) and 1.8 (6.0) μg/kg, respectively. Relative standard deviations of intraday and inter-day assay under three spiked levels were 4.4-12.0% and 6.8-14.6%, respectively
Template and target information: aminoglycoside antibiotic, streptomycin, gentamicin, spectinomycin, dihydrostreptomycin
Author keywords: molecularly imprinted polymer, HILIC-MS, MS, Aminoglycoside antibiotics, solid phase extraction, Honey samples


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