MIPdatabase
Authors: Karimian N, Zavar MHA, Chamsaz M, Turner APF, Tiwari A
Article Title: On/off-switchable electrochemical folic acid sensor based on molecularly imprinted polymer electrode.
Publication date: 2013
Journal: Electrochemistry Communications
Volume: 36
Page numbers: 92-95.
DOI: 10.1016/j.elecom.2013.09.014
Alternative URL: http://www.sciencedirect.com/science/article/pii/S1388248113003573
Abstract: The combination of smart polymers with molecular imprinting offers a powerful tool to design more effective sensors and medical devices. In this study, a temperature sensitive amine-terminated poly(N-isopropylacrylamide) block with (N,N'-methylenebisacrylamide) cross-linker along with o-phenylenediamine was electropolymerised on a gold electrode in the presence of folic acid (FA) as template to produce an on/off-switchable molecularly imprinted polymer (MIP) affinity sensor for folic acid. Differential pulse voltammetry and cyclic voltammetry were used to characterise the FA-imprinted layer. Incubation of the MIP-modified electrode with FA resulted in a suppression of the ferro/ferricyanide redox process. The highest sensitivity of this temperature gated on/off-switchable folic acid sensor was achieved at 22 °C. Such switchable affinity materials offer considerable potential for the design of highly selective and controllable biosensors and immunoassays
Template and target information: folic acid, FA
Author keywords: molecularly imprinted polymer, smart polymers, Temperature switchable electrode, Folic acid electrochemical sensor
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