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Reference type: Journal
Authors: Chen JM, Lv QM, Wu GM, Chu HQ
Article Title: Design and Simulation of a Molecularly Imprinted Sensor Integrated with a Thin-film Bulk Acoustic Resonator for Drug Detection.
Publication date: 2013
Journal: Optics and Precision Engineering
Volume: 21
Issue: (9)
Page numbers: 2272-2278.
Alternative URL: http://www.eope.net/EN/abstract/abstract14784.shtml

Abstract: Drug abuse is a serious problem which affects both the health of individual human beings and also general social stability. On way to address this problem is through testing and surveillance. Hence, a highly sensitive and selective sensor which can detect drug molecules in a liquid environment has been studied. Combining the high selectivity of a functionalized substrate prepared using a molecular imprinting technique (MIT) and the high sensitivity of a thin-film bulk acoustic resonator (FBAR), we proposed to integrate them with micro fluidics technology to produce a drug detection sensor which can operate in a liquid environment. We designed a model of the micro fluidic system with the MIT plus FBAR-based drug detection sensor and performed a detailed theoretical derivation and analysis. Finally, the sensor model was simulated using practical operating parameters. The results show that the quality of the mass loudness per unit area of the sensor is up to 0.8 pg/Hz/cm2, which is much higher than the quality of a conventional quartz crystal microbalance (QCM) sensor. This advantage can greatly enhance the performance of the sensor for drug detection in a liquid environment.
Author keywords: Micro-Electro-Mechanical Systems (MEMS), Film Bulk Acoustic Resonator (FBAR), Molecular imprinting technique (MIT), Microchannel, Drug Detection Sensor


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