Authors: Rashid BA
, Briggs RJ
, Hay JN
, Stevenson D
Preliminary evaluation of a molecular imprinted polymer for solid-phase extraction of tamoxifen.
Publication date: 1997
Journal: Analytical Communications
Abstract: A molecular imprinted polymer, prepared around a tamoxifen template, has been synthesised. The feasibility of using this polymer for solid-phase extraction of tamoxifen from biological samples has been investigated. The results show that the drug can be quantitatively retained and eluted from the polymer using acetonitrile-acetic acid. Experiments with biological fluids indicate that clean traces are obtained for HPLC with UV detection using this type of protocol
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