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Reference type: Journal
Authors: del Sole R, Scardino A, Lazzoi MR, Mergola L, Scorrano S, Vasapollo G
Article Title: A molecularly imprinted polymer for the determination of neopterin.
Publication date: 2013
Journal: Microchimica Acta
Volume: 180
Issue: (15-16)
Page numbers: 1401-1409.
DOI: 10.1007/s00604-013-0982-y
Alternative URL: https://www.researchgate.net/publication/257446302_A_molecularly_imprinted_polymer_for_the_determination_of_neopterin

Abstract: A molecularly imprinted polymer (MIP) for the specific retention of neopterin has been developed. A set of 6 polymers was prepared by radical polymerization under different experimental condition using methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinker, with the aim to understand their influence on the efficiency of the MIP. The performance of each MIP was tested in batch experiments via their binding capacity. The MIP prepared in the presence of nickel ions in dimethylsulfoxide-acetonitrile mixture (P4) exhibited the highest binding capacity for neopterin (260 μmol per gram of polymer). A selectivity study with two other pteridines demonstrated the polymer P4 also to possess the best selectivity
Template and target information: neopterin
Author keywords: Molecularly imprinted polymers, neopterin, Tumor marker, nickel


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